What is released in a skin incision that increases coagulation?

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Multiple Choice

What is released in a skin incision that increases coagulation?

Explanation:
When tissue is injured, cells release thromboplastin (tissue factor), which kicks off the extrinsic coagulation pathway by forming a complex with factor VIIa to activate factor X. This leads to thrombin generation and the conversion of fibrinogen to fibrin, forming a clot. The other substances are present in the blood system but are not the immediate trigger released at the wound: fibrinogen and prothrombin are circulating coagulation proteins, and platelet factor 4 is released from platelets and modulates coagulation rather than initiating it.

When tissue is injured, cells release thromboplastin (tissue factor), which kicks off the extrinsic coagulation pathway by forming a complex with factor VIIa to activate factor X. This leads to thrombin generation and the conversion of fibrinogen to fibrin, forming a clot. The other substances are present in the blood system but are not the immediate trigger released at the wound: fibrinogen and prothrombin are circulating coagulation proteins, and platelet factor 4 is released from platelets and modulates coagulation rather than initiating it.

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