In coagulation, which initiator is tissue factor?

In coagulation, which initiator is tissue factor?

• A. Thromboplastin
• B. Thrombin
• C. Platelets
• D. Fibrin

Answer: (A)

Tissue factor serves as the trigger for the extrinsic coagulation pathway. It binds to factor VIIa to form a TF-VIIa complex, which activates factor X (and IX) to drive thrombin formation and fibrin creation. In laboratory testing, the initiator used to start this pathway is thromboplastin, which is essentially tissue factor prepared from tissue. So tissue factor is thromboplastin in the context of initiating coagulation. Thrombin is the enzyme that converts fibrinogen to fibrin, platelets provide surfaces and mediators, and fibrin is the final clot mesh.

Tissue factor serves as the trigger for the extrinsic coagulation pathway. It binds to factor VIIa to form a TF-VIIa complex, which activates factor X (and IX) to drive thrombin formation and fibrin creation. In laboratory testing, the initiator used to start this pathway is thromboplastin, which is essentially tissue factor prepared from tissue. So tissue factor is thromboplastin in the context of initiating coagulation. Thrombin is the enzyme that converts fibrinogen to fibrin, platelets provide surfaces and mediators, and fibrin is the final clot mesh.